Diazepam and alcohol interaction






Interaction of diazepam or lorazepam with alcohol - Springer

10/21/2014
09:37 | Author: Taylor Sanders

Diazepam and alcohol interaction
Interaction of diazepam or lorazepam with alcohol - Springer

Nine healthy volunteers in a double-blind, cross-over trial received diazepam (DZ) 10 mg, lorazepam (LZ) 2.5 mg, or placebo (P). Serum benzodiazepine (BZ).

Nine healthy volunteers in a double-blind, cross-over trial received diazepam (DZ) 10 mg, lorazepam (LZ) 2.5 mg, or placebo (P). Serum benzodiazepine (BZ) was bioassayed (radioreceptor method) and psychomotor tests were carried out on Day 1 (before and 1 h after the first dose) and on Day 4 (before and after the fifth dose). In each session alcohol 1 g/kg was administered 1.5 h after drug intake and the measurements were repeated twice. Serum BZ concentrations, expressed as DZ equivalents (µg/l), ranged from 390 to 440 and from 990 to 1240 measured 2 h 45 min after the first doses of DZ and LZ, respectively.

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Interaction of diazepam or lorazepam with alcohol. Psychomotor

12/20/2014
07:14 | Author: Samantha Price

Diazepam and alcohol interaction
Interaction of diazepam or lorazepam with alcohol. Psychomotor

Eur J Clin Pharmacol. 1985;28(5):559-65. Interaction of diazepam or lorazepam with alcohol. Psychomotor effects and bioassayed serum levels after single and.

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Nine healthy volunteers in a double-blind, cross-over trial received diazepam (DZ) 10 mg, lorazepam (LZ) 2.5 mg, or placebo (P). Serum benzodiazepine (BZ) was bioassayed (radioreceptor method) and psychomotor tests were carried out on Day 1 (before and 1 h after the first dose) and on Day 4 (before and after the fifth dose). In each session alcohol 1 g/kg was administered 1.5 h after drug intake and the measurements were repeated twice. Serum BZ concentrations, expressed as DZ equivalents (microgram/l), ranged from 390 to 440 and from 990 to 1240 measured 2 h 45 min after the first doses of DZ and LZ, respectively. On Day 1 BZ alone impaired psychomotor skills. LZ affected performance more in objective tests, but DZ was subjectively rated as causing more drowsiness. After the intake of alcohol, all groups showed impairment in various tests. The rank order was LZ + alcohol greater than DZ + alcohol greater than P + alcohol. Residual BZ activity on Day 4, measured 18 h after the fourth dose, averaged 290 and 450 micrograms/l after DZ and LZ, respectively. At the same time slight residual exophoria was found after both BZs. Tolerance to BZs on Day 4 was unambiguous only when drug effects were related to the bioassayed serum levels. The combined action of BZs and alcohol was similar on Days 1 and 4. However, a tendency to an increased drug-alcohol interaction during advanced treatment with DZ was seen in the body sway test.(ABSTRACT TRUNCATED AT 250 WORDS).

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Pharmacokinetic and pharmacodynamic interactions of bretazenil

10/19/2014
05:29 | Author: Nick Barnes

Diazepam and alcohol interaction
Pharmacokinetic and pharmacodynamic interactions of bretazenil

1Interaction between alcohol and bretazenil (a benzodiazepine partial agonist in animals) was studied with diazepam as a comparator in a randomized.

1 Interaction between alcohol and bretazenil (a benzodiazepine partial agonist in animals) was studied with diazepam as a comparator in a randomized, double-blind, placebo controlled six-way cross over experiment in 12 healthy volunteers, aged 19−26 years.

8 Contrary to the results in animals, there were no indications for a dissociation of the sedative and anxiolytic effects of bretazenil in man.

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6 Bretazenil with or without alcohol, and diazepam+alcohol had marked effects. Because subjects were often too sedated to perform the adaptive tracking test and the eye movement tests adequay, ceiling effects may have affected the outcome of these tests.

5 There were no consistent indications for synergistic, supra-additive pharmacodynamic interactions between alcohol and bretazenil or diazepam.

4 Compared with placebo all treatments caused significant decrements in performance. Overall, the following sequence was found for the magnitude of treatment effects: bretazenil+alcohol>diazepam+alcohol≥bretazenil> diazepam>alcohol>placebo.

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3 CNS effects were evaluated between 0 and 3.5 h after drug administration by smooth pursuit and saccadic eye movements, adaptive tracking, body sway, digit symbol substitution test and visual analogue scales.

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7 No significant pharmacokinetic interactions were found.

2 Bretazenil (0.5 mg), diazepam (10 mg) and matching placebos were given as single oral doses after intravenous infusion of alcohol to a steady target-blood concentration of 0.5 g l−1 or a control infusion of 5% w/v glucose at 1 week intervals.

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Pharmacokinetic and pharmacodynamic interactions of bretazenil

8/18/2014
03:08 | Author: Samantha Price

Diazepam and alcohol interaction
Pharmacokinetic and pharmacodynamic interactions of bretazenil

Interaction between alcohol and bretazenil (a benzodiazepine partial agonist in animals) was studied with diazepam as a comparator in a randomized.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Valium and alcohol - Benzodiazepines - Take a Chill Pill

6/17/2014
01:25 | Author: Taylor Sanders

Diazepam and alcohol interaction
Valium and alcohol - Benzodiazepines - Take a Chill Pill

Valium and alcohol - posted in Benzodiazepines - Take a Chill Pill!: Hi all! There is an interaction with all benzos with alcohol. However, this.

Posted 11 December 2005 - 05:05 PM.

Posted 11 December 2005 - 02:16 PM.

Hairpants for hairpants :).

Posted 11 December 2005 - 02:56 PM Member.

Posted 08 June 2010 - 11:22 AM.

Posted 12 December 2005 - 09:46 AM.

Waaaaiiit a minute... I knew it. WTF NOS.

Posted 08 June 2010 - 11:17 AM.

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Posted 11 December 2005 - 11:53 AM Member.

hey, from experience.. one word: Blackout... ahhh, those were the days.. for real, be safe. good luck and have fun. matt.

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Thanks for the replies so far! After thinking things through I have decided to just stick to the non-alcoholic beer whenever averyone else is enjoying everything else. Luckily they (the breweries) have gotten non-alcoholic beer to taste like beer. But when will someone make a non-alcoholic wine that does not taste like grape juice? Oh how I miss a glass or four of a nice Italian red wine... Take care out there! H. Member.

Dx : Schizophrenia, paranoid type with panic attacks. Obsessive Compulsive Personality Trait, epilepsy Rx : 300mg Clozapine, 1500mg Keppera, 60mg Prozac, 160mg Zeldox, 4mg Reboxetine, 3 oxazepam morning and lunch, 3 in the evening Ex Rx: Luvox, Paxil, Risperdel, Xanax, Seroquel, Abilify, Zyprexa, Tolvon, Mirtazapine, diazepam. Back to top #6 JustAnotherNut JustAnotherNut Member.

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Posted 11 December 2005 - 08:07 PM.

Edited by Helena, 11 December 2005 - 02:18 PM.

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