Antidote for diazepam poisoning






In wake of Syrian chemical attacks, scientists seek to improve sarin

7/16/2014
01:34 | Author: Jessica Kelly

Roche diazepam images
In wake of Syrian chemical attacks, scientists seek to improve sarin

Syrian doctors had only limited amounts of antidotes against the nerve sarin poisoning, the one most likely to be replaced first is diazepam.

Drugs, drugs and more drugs.

With an eye to long-term neuroprotection, Butera and his colleagues are now looking for compounds that can both reactivate AChE (like 2-PAM does) at the same time that they block a DNA-binding protein called poly(ADP-ribose) polymerase 1 (PARP1). This enzyme is known to be involved in tissue injury and neurodegeneration, and many experimental PARP-1 inhibitors are now in clinical development for the treatment of cancer and stroke.

Of course, none of these experimental therapeutics will likely be ready in time to help Syrian civilians if or when nerve agents are used again during the country’s ongoing civil war.

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Effect of diazepam on the effectiveness of antidote therapy in

5/15/2014
01:28 | Author: Lauren Wood

Roche diazepam images
Effect of diazepam on the effectiveness of antidote therapy in

ABSTRACT The currently used antidotal treatment of intoxication with nerve agents, consisting of an anticholinergic drug and an acetylcholinesterase reactivator.

ABSTRACT The currently used antidotal treatment of intoxication with nerve agents, consisting of an anticholinergic drug and an acetylcholinesterase reactivator, is often completed with the anticonvulsive drug diazepam to prevent poisoned organisms from centrally mediated seizures and subsequent tonic-clonic convulsions. The aim of this study was to find out whether the complementation of the antidotal treatment with diazepam can influence antidotal treatment-induced elimination of acute lethal effects of the chosen nerve agent--soman. In experiments on mice, the values of medium lethal dose of soman in the case of 24 h surviving of soman-exposed mice, treated with the basic antidotes involving various types of anticholinergic drugs and acetylcholinesterase reactivators, were evaluated and compared to the values of medium lethal dose of soman in mice treated with antidotes completed with diazepam. Our findings confirm that diazepam is able to enhance the efficacy of basic antidotal treatment to eliminate acute lethal effects of soman if atropin is used as anticholinergic drug. On the other hand, no ability of diazepam to enhance soman-induced lethal effects was demonstrated if an anticholinergic drug with central effects such as benactyzine, biperiden or scopolamin was used. The ability of diazepam to influence the efficacy of antidotes to eliminate soman-induced acute lethal effects was only observed in the case of using the oxime HI-6 as acetycholinesterase reactivator. The most perspective antidotal mixture against soman, consisting of the oxime HI-6 and atropine, should be complemented by diazepam no only because of the prevention of poisoned organisms from centrally mediated seizures and subsequent tonic-clonic convulsions but also because of the increase in the ability of antidotal treatment to eliminate soman-induced acute lethal effects.

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